Z-Ile-Leu-aldehyde

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].

Product Specifications

CAS Number

[161710-10-7]

Product Name Alternative

Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII

UNSPSC

12352005

Target

Apoptosis; Notch; γ-secretase

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Z-Ile-Leu-aldehyde.html

Purity

98.0

Solubility

DMSO : ≥ 41 mg/mL

Smiles

O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CC(C)C)=O)[C@@H](C)CC

Molecular Formula

C20H30N2O4

Molecular Weight

362.46

References & Citations

[1]Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.|[2]Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217.