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PNKP Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Polynucleotide kinase 3'-phosphatase

Gene Aliases

PNK, AOA4, MCSZ, CMT2B2, EIEE10

Gene ID

11284

Swiss Prot

Q96T60

Accession Number

NP_009185

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PNKP

Target

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.

Partner Proteins

ZNF639; IKZF1; TNIP1; ZBTB14; RPA3; RPA2; RPA1; EED; rev; KDM1A; SUV39H1; HNRNPU; GZMK; XRCC6; CDK11B; PARP1; MCM3; SMAD5; LIG4; XRCC1; TCOF1; SSRP1; PRKDC; NRD1; NASP; MCM5; C18orf25; UBE2O; GEMIN4; AGTPBP1; PNKP; SUPT16H; VPRBP; NOLC1; TRIM26; XRCC5; XR

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MGEVEAPGRLWLESPPGGAPPIFLPSDGQALVLGRGPLTQVTDRKCSRTQ

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

57kDa

Protein Length

521

NCBI Gene Symbol

PNKP

Host or Source

Rabbit

Protein Name

Bifunctional polynucleotide phosphatase/kinase

Gene Name URL

PNKP

Nucleotide Accession Number

NM_007254

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