COPS8 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)

Gene Aliases

COP9, CSN8, SGN8

Gene ID

10920

Swiss Prot

Q99627

Accession Number

NP_006701

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human COPS8

Target

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Partner Proteins

USHBP1; GPS1; cul1; WDR77; SRRT; COPS7A; VIM; COPS4; FBXO6; FBXW4; COPS5; vpr; IRF5; DDIT3; COPS2; COPS3; COPS6; PINK1; RFWD2; CUL4A; UBC; LRR1; DDA1; DDB2; DCUN1D1; VPRBP; CUL2; CUL3; CUL4B; CUL5; NEDD8; JUN; GFER; ERCC8; DDB1; CTNNB1; RAE1; COPS8; EIF3E

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLE

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

23kDa

Protein Length

209

NCBI Gene Symbol

COPS8

Host or Source

Rabbit

Protein Name

COP9 signalosome complex subunit 8

Gene Name URL

COPS8

Nucleotide Accession Number

NM_006710

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