4E2RCat
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
Product Specifications
CAS Number
[432499-63-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Eukaryotic Initiation Factor (eIF) ; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4E2RCat.html
Purity
98.0
Solubility
DMSO : 23.33 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC(C2=CC=C(/C=C(SC(N3CC4=CC=CC=C4)=S)/C3=O)O2)=CC=C1Cl
Molecular Formula
C22H14ClNO4S2
Molecular Weight
455.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85 (13) :6381-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4
Available Sizes
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