POLR3C Antibody - middle region

Click here to learn more about Aviva's By-Request Conjugation Service.//here

Product Specifications

CAS Number

9007-83-4

Gene Name

Polymerase (RNA) III (DNA directed) polypeptide C (62kD)

Gene Aliases

C82, RPC3, RPC62

Gene ID

10623

Swiss Prot

Q9BUI4

Accession Number

NP_006459

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human POLR3C

Target

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. POLR3C may direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. POLR3C may be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. POLR3C plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses.POLR3C acts as nuclear and cytosolic DNA sensor involved in innate immune response. POLR3C can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Partner Proteins

PNMA5; CEP63; ROPN1; TNR; ROCK1; TRIM27; UBC; VCP; POLR1C; POLR2E; APP; POLR3H; NOC4L; RSL1D1; POLR3A; POLR3G; POLR3F; GTF3C4; POLR3D; TBP; GTF3C3; GTF3C5; GTF3C2; GTF3C1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

VEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDASEIQV

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 90%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

60kDa

Protein Length

534

NCBI Gene Symbol

POLR3C

Host or Source

Rabbit

Protein Name

DNA-directed RNA polymerase III subunit RPC3

Gene Name URL

POLR3C

Nucleotide Accession Number

NM_006468

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

MBS6170887-01 0.1 mL

CDX4 (Caudal Type Homeobox 4) (Biotin)

Ask

View Details

MBS6170887-02 5x 0.1 mL

CDX4 (Caudal Type Homeobox 4) (Biotin)

Ask

View Details

H8256 96 Tests

Transmembrane protein 14D (TMEM14D) Human ELISA Kit

Ask

View Details

MC200707 10 µg

Gpr89 (NM_026229) Mouse Untagged Clone

Ask

View Details

MBS6347132-01 0.2 mL

SH2D1A, CT (SH2D1A, DSHP, SAP, SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP) (APC)

Ask

View Details

MBS6347132-02 5x 0.2 mL

SH2D1A, CT (SH2D1A, DSHP, SAP, SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP) (APC)

Ask

View Details