TOB1 antibody - middle region (ARP52105_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Transducer of ERBB2, 1

Gene Aliases

TOB, TROB, APRO5, APRO6, PIG49, TROB1

Gene ID

10140

Swiss Prot

P50616

Accession Number

NP_005740

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TOB1

Target

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

Partner Proteins

CORO7; APP; DTL; CDC7; PABPC1; CHAF1A; PAN2; UBR5; ELAVL1; SMAD3; CTNNB1; UBC; SKP2; SCMH1; MARCKS; SETDB1; CNOT7; SMAD9; SMAD5; SMAD6; SMAD1; SMAD2; SMAD4; MAPK1; ERBB2; RPS6KA1; MAPK9

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKT

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 82%; Pig: 93%; Rat: 92%; Yeast: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

38kDa

Protein Length

345

NCBI Gene Symbol

TOB1

Host or Source

Rabbit

Protein Name

Protein Tob1

Gene Name URL

TOB1

Nucleotide Accession Number

NM_005749

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