OAS1 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Gene Aliases

OIAS, IFI-4, OIASI, E18/E16

Gene ID

4938

Swiss Prot

P00973-3

Accession Number

NP_001027581

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human OAS1

Target

This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

Partner Proteins

EXOC5; TRIM27; ACTN1; PRMT6; WBSCR22; RPL30; HCVgp1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

RRQLTKPRPVILDPADPTGNLGGGDPKGWRQLAQEAEAWLNYPCFKNWDG

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 87%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 86%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

46 kDa

Protein Length

414

NCBI Gene Symbol

OAS1

Host or Source

Rabbit

Protein Name

2'-5'-oligoadenylate synthase 1

Gene Name URL

OAS1

Nucleotide Accession Number

NM_001032409

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

GWB-A506AA 0.1 mL

ERCC1 Antibody

Ask

View Details

MBS6150445-01 0.1 mL

VNN1 (Vascular Non-inflammatory Molecule 1, Vanin-1, Pantetheinase, Pantetheine Hydrolase, Tiff66, HDLCQ8) (FITC)

Ask

View Details

MBS6150445-02 5x 0.1 mL

VNN1 (Vascular Non-inflammatory Molecule 1, Vanin-1, Pantetheinase, Pantetheine Hydrolase, Tiff66, HDLCQ8) (FITC)

Ask

View Details

E51A05822 100 µL

PAR6A Antibody

Ask

View Details

MBS9407822-01 0.1 mL

KLRG1 antibody

Ask

View Details

MBS9407822-02 5x 0.1 mL

KLRG1 antibody

Ask

View Details