What is the catalog number for FZR1 antibody - N-terminal region (ARP51279_P050)?

The catalog number for FZR1 antibody - N-terminal region (ARP51279_P050) is ARP51279_P050.

What sizes are available for FZR1 antibody - N-terminal region (ARP51279_P050)?

FZR1 antibody - N-terminal region (ARP51279_P050) is available in the following size(s): 100 µL.

Is FZR1 antibody - N-terminal region (ARP51279_P050) in stock?

FZR1 antibody - N-terminal region (ARP51279_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

FZR1 antibody - N-terminal region (ARP51279_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Fizzy/cell division cycle 20 related 1 (Drosophila)

Gene Aliases

FZR, CDH1, FZR2, HCDH, HCDH1, CDC20C

Gene ID

51343

Swiss Prot

Q9UM11

Accession Number

NP_057347

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human FZR1

Target

FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.

Partner Proteins

ZC3HC1; CDC25A; CCNB1; UBE2S; UBE2C; PTTG1; UBE2D2; TP53; CDR2; UBE2K; ANAPC4; PDS1; STAU1; CDK2; CDC27; RACGAP1; FOXM1; HECW2; PHF8; BTRC; CCNA1; UBC; SOX2; SKP2; PLK1; CUL1; CUEDC2; CDC20; kif22; SIRT2; CLSPN; ANAPC11; CDC14B; VHL; PTEN; EYA1; DAXX; BUB

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDN

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

55kDa

Protein Length

493

NCBI Gene Symbol

FZR1

Host or Source

Rabbit

Protein Name

Fizzy-related protein homolog

Gene Name URL