PHC2 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Polyhomeotic homolog 2 (Drosophila)

Gene Aliases

PH2, EDR2, HPH2

Gene ID

1912

Swiss Prot

Q8IXK0

Accession Number

NP_932157

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PHC2

Target

In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for the stable inheritance of gene activity. PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to the Drosophila PcG protein 'polyhomeotic' (Ph) and is known to heterodimerize with EDR1 and colocalize with BMI1 in interphase nuclei of human cells. The specific function in human cells has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene.

Partner Proteins

FAM74A4; FAM74A1; FAM13C; FAM124A; MAGEB6; ZMAT2; ZNF417; MAB21L3; SSX2IP; TRIM41; ZGPAT; L3MBTL3; PCGF5; SPATC1L; FAM161A; ENKD1; KBTBD7; SYT16; THAP7; AEN; CARD9; CBX8; C1orf109; SFMBT1; PRPF31; PPP1R16B; KAT5; PCGF3; RWDD2B; ZBTB24; MORF4L2; RBM39; AP1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GGSGRPTGPQISVYSGIPDRQTVQVIQQALHRQPSTAAQYLQQMYAAQQQ

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

91kDa

Protein Length

858

NCBI Gene Symbol

PHC2

Host or Source

Rabbit

Protein Name

Polyhomeotic-like protein 2

Gene Name URL

PHC2

Nucleotide Accession Number

NM_198040

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