SIN3B Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

SIN3 transcription regulator homolog B (yeast)

Gene Aliases

KIAA0700

Gene ID

23309

Swiss Prot

O75182

Accession Number

NP_056075

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SIN3B

Target

SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription

Partner Proteins

SOX2; HDAC1; HDAC2; UBC; ESR1; AR; TFAP4; TP53; SUMO2; KLF16; MORF4L1; MORF4L2; MRGBP; KDM5A; CIITA; NR1D2; COPS2; SMN1; PBX1; REST; ZBTB4; ARID4A; MYT1; MXI1; SAP25; SMARCE1; SMARCB1; SMARCA4; SMARCA2; CBFA2T3; RNF220; ZBTB16; SETDB1; HDAC9; IKZF4; IKZF1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMAD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rat: 79%; Zebrafish: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

133kDa

Protein Length

1162

NCBI Gene Symbol

SIN3B

Host or Source

Rabbit

Protein Name

Paired amphipathic helix protein Sin3b

Gene Name URL

SIN3B

Nucleotide Accession Number

NM_015260

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