SIN3B antibody - middle region (ARP50590_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

SIN3 transcription regulator homolog B (yeast)

Gene Aliases

KIAA0700

Gene ID

23309

Swiss Prot

O75182

Accession Number

NP_056075

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SIN3B

Target

SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription

Partner Proteins

SOX2; HDAC1; HDAC2; UBC; ESR1; AR; TFAP4; TP53; SUMO2; KLF16; MORF4L1; MORF4L2; MRGBP; KDM5A; CIITA; NR1D2; COPS2; SMN1; PBX1; REST; ZBTB4; ARID4A; MYT1; MXI1; SAP25; SMARCE1; SMARCB1; SMARCA4; SMARCA2; CBFA2T3; RNF220; ZBTB16; SETDB1; HDAC9; IKZF4; IKZF1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMAD

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol