NUMA1 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Nuclear mitotic apparatus protein 1

Gene Aliases

NUMA, NMP-22

Gene ID

4926

Swiss Prot

Q14980

Accession Number

NP_006176

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NUMA1

Target

NuMA is a structural element in maintaining nuclear integrity. A critical spindle pole-associated mechanism, called the END (Emi1/NuMA/dynein-dynactin) network, spatially restricts APC/C activity in early mitosis. The entire coding region and exon-intron boundaries of NuMa were screened in 92 familial breast cancer patients. But the results do not support the role of NuMA variants as breast cancer susceptibility alleles.

Partner Proteins

CCDC57; GMCL1; BRAP; DVL3; DVL2; DVL1; UBC; LGR4; ERG; RPA3; RPA2; RPA1; RNF2; EZH2; BMI1; SUZ12; EED; YWHAQ; LMNA; CBX6; WHSC1; HSP90AB1; HSP90AA1; ESR1; CDK6; VCP; SMURF1; MDC1; TP53BP1; ECT2; NCSTN; DDB1; EMILIN1; DYNLL1; RAE1; NUP98; CDK2; TERF2IP; TE

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

238kDa

Protein Length

2115

NCBI Gene Symbol

NUMA1

Host or Source

Rabbit

Protein Name

Nuclear mitotic apparatus protein 1

Gene Name URL

NUMA1

Nucleotide Accession Number

NM_006185

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