ATXN3 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Ataxin 3

Gene Aliases

AT3, JOS, MJD, ATX3, MJD1, SCA3

Gene ID

4287

Swiss Prot

P54252

Accession Number

NP_004984

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human ATXN3

Target

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG) n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Partner Proteins

UBC; NEDD8; ATXN3; TRIM63; SQSTM1; VCP; ITCH; PARK2; MGRN1; TUBB; HDAC6; TUBA1A; ELC1; ELA1; SYVN1; BAG3; BCL2L1; STUB1; SUMO1; APP; RFFL; TRIM55; SPRTN; PJA1; TRIM54; USP21; UBE2L3; ARHGDIA; ASIC1; RAD23B; RAD23A; ARHGAP19; C16orf70; TEX11; PICK1; GSK3B

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNAL

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol