AV-153 (free base)

AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly (ADP) ribosylation. AV-153 free base has anti-cancer activity[1][2][3].

Product Specifications

CAS Number

[19350-66-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/av-153-free-base.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C(O)=O)OCC

Molecular Formula

C14H19NO6

Molecular Weight

297.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587 (1-2) :52-8.|[2]E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7.|[3]Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel) . 2018 Sep 19;7 (9) :123.