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CRYAB antibody - C-terminal region (ARP48196_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

Crystallin, alpha B

Gene Aliases

MFM2, CRYA2, CTPP2, HSPB5, CMD1II, CTRCT16, HEL-S-101

Gene ID

1410

Swiss Prot

P02511

Accession Number

EAW67166

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human CRYAB

Target

Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.

Partner Proteins

CRYAB; CRYAA; KRTAP19-5; KRTAP8-1; TRAPPC6A; MRPL11; TNPO2; ACOT7; HSPB1; CASP7; CASP3; CASP2; PIDD1; DDX20; CRADD; B2M; APOC2; XIAP; CASP12; SOD1; HSPB2; HBA1; CASP9; CASP8; CASP6; ASB5; SMAD4; TRIM33; UBC; CCL22; CTNNB1; CRYGD; CDH1; SNCA; GFAP; FGF2; F

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

KYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERTIPITREEKPAVT

Applications

WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 92%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

20kDa

Protein Length

175

NCBI Gene Symbol

CRYAB

Host or Source

Rabbit

Protein Name

Alpha-crystallin B chain

Gene Name URL

CRYAB

Nucleotide Accession Number

NM_001885

Frequently Asked Questions

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