Taccalonolide A

Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities[1][2]. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis[1]. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells[3].

Product Specifications

CAS Number

[108885-68-3]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/taccalonolide-a.html

Purity

99.29

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]([C@@H](OC(C)=O)[C@]3([H])[C@]2([H])[C@@H](C=C(O4)[C@@]3([C@](O)(C4=O)C)C)C)([H])[C@@]([C@H]5O)([H])[C@]([C@]6([C@H]([C@@H](O7)[C@@H]7C[C@]6([H])C5=O)OC(C)=O)C)([H])[C@H](OC(C)=O)[C@@H]1OC(C)=O

Molecular Formula

C36H46O14

Molecular Weight

702.74

References & Citations

[1]Tinley TL, et al. Taccalonolides E and A: Plant -derived steroids with microtubule-stabilizing activity. Cancer Res. 2003 Jun 15;63 (12) :3211-20.|[2]Risinger AL, et al. Taccalonolides: Novel microtubule stabilizers with clinical potential. Cancer Lett. 2010 May 1;291 (1) :14-9.|[3]Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68 (21) :8881-8.