ATRX Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Similar to putative DNA dependent ATPase and helicase

Gene Aliases

JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX

Gene ID

546

Swiss Prot

P46100-6

Reactivity

Human, Dog, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Target

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Partner Proteins

SUMO2; SUMO3; RAD51; H3F3A; PRKDC; PML; NBN; MRE11A; HIST1H1C; XRCC6; DAXX; SUPT16H; RAD50; HIST1H4J; HIST2H2BE; HIST1H2BL; HIST1H2AB; XRCC5; TP53; SSRP1; RPA1; RAD9A; RAD1; ZNF512B; UL82; NEK1; BLM; HIST2H3C; ZBED1; UBC; SVIL; CALM1; WRN; HIST1H3A; CBX5

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol