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MBTPS2 Antibody - N-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Membrane bound transcription factor peptidase, site 2

Gene Aliases

S2P, IFAP, KFSD, OI19, KFSDX, OLMSX, BRESEK

Gene ID

51360

Swiss Prot

O43462

Accession Number

NP_056968

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MBTPS2

Target

This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

Partner Proteins

UBC; ATF6B

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

VGGWTVVYLTDLVLKSSVYFKHSYEDWLENNGLSISPFHIRWQTAVFNRA

Applications

WB

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

57 kDa

Protein Length

519

NCBI Gene Symbol

MBTPS2

Host or Source

Rabbit

Protein Name

Membrane-bound transcription factor site-2 protease

Gene Name URL

MBTPS2

Nucleotide Accession Number

NM_015884.3

Frequently Asked Questions

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