SPTLC1 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

Serine palmitoyltransferase, long chain base subunit 1

Gene Aliases

HSN1, LBC1, LCB1, SPT1, SPTI, HSAN1

Gene ID

10558

Swiss Prot

O15269

Accession Number

NP_006406

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human SPTLC1

Target

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPTLC1 is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in SPTLC1 gene were identified in patients with hereditary sensory neuropathy type 1. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified.

Partner Proteins

UBC; FBXO6; EGFR; ADRB2; CFTR; ABCA1; UBD; AUP1; MYC; ATG4C; ORMDL3; SPTLC2; C20orf24; MAGED1; RGS20

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKY

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

53 kDa

Protein Length

473

NCBI Gene Symbol

SPTLC1

Host or Source

Rabbit

Protein Name

Serine palmitoyltransferase 1

Gene Name URL

SPTLC1

Nucleotide Accession Number

NM_006415

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

YLD6592-01 50 µL

Rabbit anti-RAB5A Antibody

Ask

View Details

YLD6592-02 100 µL

Rabbit anti-RAB5A Antibody

Ask

View Details

332199 100 µL

RCL (C6orf108, Deoxyribonucleoside 5'-monophosphate N-glycosidase, c-Myc-responsive protein Rcl)

Ask

View Details

RR212799L3 10 µg

RGD1307947 (NM_001014083) Rat Tagged Lenti ORF Clone

Ask

View Details