DCC antibody - middle region (ARP46583_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

Deleted in colorectal carcinoma

Gene Aliases

CRC18, CRCR1, MRMV1, HGPPS2, IGDCC1, NTN1R1

Gene ID

1630

Swiss Prot

P43146

Accession Number

NP_005206

Reactivity

Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human DCC

Target

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.

Partner Proteins

UBC; ALB; BARD1; sina; UBI4; SIAH2; EIF4E3; EIF2A; EIF5A2; NTN1; RPL23; EIF2S2; EIF2B2; EIF2B4; EZR; RPS24; RPS13; RPS10; RPS6; RPS4X; RPL38; RPL28; RPL13; RPL5; PTK2; MAPK1; RPL10A; EIF3E; EIF4E; EIF2S3; EIF2B1; EIF1AX; ADORA2B; APPL1; CASP9; SIAH1; MAPK

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PIGQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQ

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

158kDa

Protein Length

1447

NCBI Gene Symbol

DCC

Host or Source

Rabbit

Protein Name

Netrin receptor DCC

Gene Name URL

DCC

Nucleotide Accession Number

NM_005215

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