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DTL antibody - N-terminal region (ARP46248_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Name

Denticleless E3 ubiquitin protein ligase homolog (Drosophila)

Gene Aliases

CDT2, RAMP, DCAF2, L2DTL

Gene ID

51514

Swiss Prot

Q9NZJ0

Accession Number

NP_057532

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DTL

Target

DTL is required for CDT1 proteolysis in response to DNA damage through the CUL4-DDB1 E3 ubiquitin-protein ligase. It seems to be necessary to ensure proper cell cycle regulation of DNA replication. DTL may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. It also may play a role in cell proliferation of NT2 embryonal carcinoma cells.

Partner Proteins

FBXO11; YWHAQ; CUL4A; YWHAZ; YWHAH; YWHAG; YWHAE; YWHAB; UBE2D1; UBC; PCNA; SFN; DDB1; FBXO18; CDT1; CUL4B; TDG; LYN; SHPRH; RAD18; COPS5; HLTF; CHEK1; CFTR; CDKN1A; DDA1; COPS4; COPS6; TOB1; COPS3; TUBG1; ATR; AURKB; TP53; MDM2; MSH2; MSH6; KAT2A; Dtl; S

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

VNQISGAHNTSDKQTPSKPKKKQNSKGLAPSVDFQQSVTVVLFQDENTLV

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

79kDa

Protein Length

730

NCBI Gene Symbol

DTL

Host or Source

Rabbit

Protein Name

Denticleless protein homolog

Gene Name URL

DTL

Nucleotide Accession Number

NM_016448

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