PSME3 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)

Gene Aliases

Ki, PA28G, HEL-S-283, PA28gamma, REG-GAMMA, PA28-gamma

Gene ID

10197

Swiss Prot

P61289-2

Accession Number

NP_789839

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human PSME3

Target

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. PSME3 is the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring.

Partner Proteins

SPG7; PRKAB2; PFDN5; BBS2; TNFAIP8L1; EAF1; ZCCHC10; PRR13; TXN2; FBXO7; DIP2A; PSME3; HUWE1; TUBGCP3; SIRT1; CREBBP; PSMD14; SHFM1; GTPBP4; MDM2; ADARB2; C1QBP; PARK2; CLK3; CLK2; YWHAQ; TBXA2R; BAG3; NPM1; ITGA4; CBX2; vpr; vif; HCVgp1; CBX4; VCAM1; UBC

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQ

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol