TNF Antibody - C-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Tumor necrosis factor

Gene Aliases

DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha

Gene ID

7124

Swiss Prot

P01375

Accession Number

NP_000585

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human TNFA

Target

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.

Partner Proteins

LAMP2; CASP8; RNF8; FADD; RIPK1; TRADD; UBE2N; UBC; TRAF2; TNFRSF1A; RAB5A; HNRNPA1; CHUK; PSMD9; OTULIN; RNF31; TNFRSF1B; NFKBIA; LYN; FYN; YWHAQ; ZFP36; OPTN; RBCK1; IKBKG; TNFAIP3; HNRNPD; ELAVL1; SHARPIN; AGO2; HSPB2; HSPB1; MAP3K7; IKBKB; TAB2; TAB1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

AVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLS

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol