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GHR Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Growth hormone receptor

Gene Aliases

GHBP, GHIP

Gene ID

2690

Swiss Prot

P10912-3

Accession Number

NP_001229391

Reactivity

Human, Dog, Horse, Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human GHR

Target

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein.

Partner Proteins

FBXW11; JAK2; GHR; GH1; BTRC; UBC; SKP1; SOCS2; STUB1; PTPRH; PTPRB; PTPN13; PTPN9; PTPN3; PTPN2; PTPN1; DUSP7; NCOA6; STAT5B; SOCS3; SOCS1; SGTA; CISH; GRB10; STAT5A; AP2A1; SHC1; TYK2; PTPN6; PTPN11; PRLR; PIK3R1; JAK1; IRS1; GH2; GRB2; STAT3; PLCG1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

YSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPW

Applications

WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 79%; Horse: 79%; Human: 100%; Pig: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

32kDa

Protein Length

294

NCBI Gene Symbol

GHR

Host or Source

Rabbit

Protein Name

Growth hormone receptor

Gene Name URL

GHR

Nucleotide Accession Number

NM_001242462

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