MARCH8 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

Membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase

Gene Aliases

MIR, CMIR, c-MIR, MARCH8, RNF178, MARCH-VIII

Gene ID

220972

Swiss Prot

Q5T0T0

Accession Number

NP_659458

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human MARCH8

Target

MARCH8 is an E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. It may also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Partner Proteins

TNFRSF10A; UBC; UBE2H; UBE2D1; TFRC; UBE2D3; IL1RAP; IL1R1; CD86

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

YVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHG

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

33kDa

Protein Length

291

NCBI Gene Symbol

45359

Host or Source

Rabbit

Protein Name

E3 ubiquitin-protein ligase MARCH8

Gene Name URL

45359

Nucleotide Accession Number

NM_145021

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

042182-ML750 100 µL

SP140, ID (SP140, LYSP100, Nuclear body protein SP140, Lymphoid-restricted homolog of Sp100, Nuclear autoantigen Sp-140, Speckled 140kD) (MaxLight 750) discontinued

Ask

View Details

A20414-1 1 mg

ST034307 1mg

Ask

View Details

247120-ML490 100 µL

HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ beta 1, CELIAC1, HLA-DQB, IDDM1) (MaxLight 490)

Ask

View Details

bs-7091R-PerCP-Cy5.5 100 µL

TP53I11 Polyclonal Antibody, PerCP-Cy5.5 Conjugated

Ask

View Details

MBS6490008-01 0.1 mL

NFKBIA (S32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBI, MAD3, IKBA) (MaxLight 650)

Ask

View Details

MBS6490008-02 5x 0.1 mL

NFKBIA (S32, 36) (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkappaBalpha, IkB-alpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBI, MAD3, IKBA) (MaxLight 650)

Ask

View Details