DTX2 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Deltex homolog 2 (Drosophila)

Gene Aliases

RNF58

Gene ID

113878

Swiss Prot

Q6XM87

Accession Number

NP_001096066

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human DTX2

Target

DTX2 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. DTX2 probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context and mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. It also functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

Partner Proteins

KRTAP26-1; RFX6; KLC3; GLYCTK; DTX2; RIMBP3; C1orf94; NCALD; PLEKHF2; TRIM54; EIF4ENIF1; ALKBH4; UBE2D4; HPCAL4; SPG21; SEC22A; SPAG8; STX12; NCS1; FAM168A; RBPMS; SEC23B; ABHD16A; VSNL1; SUMO1; UBE2D3; UBE2D1; UBC; TRIP6; QARS; HDC; GOLGA2; FHL2; ARNT2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

EDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLE

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol