RAD18 Antibody - middle region

Product Specifications

CAS Number

9007-83-4

Gene Name

RAD18 homolog (S. cerevisiae)

Gene Aliases

RNF73

Gene ID

56852

Swiss Prot

Q9NS91

Accession Number

NP_064550

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human RAD18

Target

RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

Partner Proteins

TAX1BP1; UBC; SHPRH; RAD18; SIVA1; USP2; UBE2B; UBE2A; HLTF; PCNA; BPLF1; USP5; DBF4; BRCA1; DZIP3; POLH; DTL; Ankrd32; MLKL; ECT2; RPL10A; TRIM23; PCGF6; TRIM8; RFC2; CPD; SPRTN; ZMYM2; MAPK8; POLN; WRNIP1; gag-pol; ORC2; SUMO2; POLK; NBN; Smc6; HIST1H2A

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEI

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

56kDa

Protein Length

495

NCBI Gene Symbol

RAD18

Host or Source

Rabbit

Protein Name

E3 ubiquitin-protein ligase RAD18

Gene Name URL

RAD18

Nucleotide Accession Number

NM_020165

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