PRPF19 antibody - middle region (ARP43158_T100)

Product Specifications

CAS Number

9007-83-4

Gene Name

PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)

Gene Aliases

PSO4, SNEV, PRP19, UBOX4, hPSO4, NMP200

Gene ID

27339

Swiss Prot

Q9UMS4

Accession Number

NP_055317

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PRPF19

Target

PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].

Partner Proteins

HUWE1; USP4; UBE2D3; SUMO2; CEP76; CEP250; TUBGCP3; CEP57; VCP; UBC; SUMO1; NEDD8; LIN28A; EXOC7; EXOC3; RPA3; RPA2; RPA1; RNF2; SUZ12; EED; rev; MEPCE; SEC13; PARK2; TARDBP; UBD; CSNK2A2; UCHL5; WHSC1; U2AF1; PRCC; HSP90AA1; HSPB1; FN1; RBM10; vif; CDC40

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

PSVVGAGEPMDLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVK

Applications

IHC, WB

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol