What is the catalog number for UBE3A antibody - N-terminal region (ARP42950_P050)?

The catalog number for UBE3A antibody - N-terminal region (ARP42950_P050) is ARP42950_P050.

What sizes are available for UBE3A antibody - N-terminal region (ARP42950_P050)?

UBE3A antibody - N-terminal region (ARP42950_P050) is available in the following size(s): 100 µL.

Is UBE3A antibody - N-terminal region (ARP42950_P050) in stock?

UBE3A antibody - N-terminal region (ARP42950_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.

UBE3A antibody - N-terminal region (ARP42950_P050)

Selected Variant

ARP42950_P050

Size: 100 µL

Product Specifications

CAS Number

9007-83-4

Gene Name

Ubiquitin protein ligase E3A

Gene Aliases

AS, ANCR, E6-AP, HPVE6A, EPVE6AP

Gene ID

7337

Swiss Prot

Q05086

Accession Number

NP_000453

Reactivity

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human UBE3A

Target

UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Partner Proteins

KLHL38; UBE2D1; UBB; TP53; TAT; AFG3L1P; ATG9A; ASAP3; AHSP; UBE3A; UBC; MEOX2; MAGEA8; JADE1; YOD1; UBE2L3; UBE2D3; PSMD14; SHFM1; ARNTL; LPP; HSF1; DR1; BTF3L4; LRSAM1; P3H1; NPLOC4; IPO11; DBNL; LSM1; ARPC1B; METTL1; SACS; ARC; RAD23A; PTPN3; CEBPA; SC

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGP

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 93%; Goat: 90%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 91%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

101kDa

Protein Length

875

NCBI Gene Symbol

UBE3A

Host or Source

Rabbit

Protein Name

Ubiquitin-protein ligase E3A

Gene Name URL

UBE3A

Nucleotide Accession Number

NM_000462

Price

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