Axin1 Antibody - N-terminal region
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Product Specifications
CAS Number
9007-83-4
Gene Aliases
Fu, Kb, Ki, Axin, fused, kinky, knobbly, AI316800
Gene ID
12005
Swiss Prot
O70239
Accession Number
XP_920000
Reactivity
Human, Mouse
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1
Target
Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.
Partner Proteins
Lrp5; Gsk3b; Prmt1; Ctnnb1; GSK3A; Trp53; Hipk2; Nck2; Lrrk2; ITCH; WWP1; MAP3K1; Kif3a; Cops2; Dvl2; Axin1; Apc; Dixdc1; Ppp2r1a; Map3k4; Ppp2ca; Rnf111; Rnf11; Smad7; Smad6; Smad3; Dvl1; Cdh2; APC2
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
TVGRDQALGARQAERPWPPHSHPSTPEPSVRNDGKRRFMGVRRQGSRGAG
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
110kDa
Protein Length
993
NCBI Gene Symbol
AXIN1
Host or Source
Rabbit
Protein Name
Axin-1
Gene Name URL
Axin1
Nucleotide Accession Number
XM_914907
Curated Selection
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