Axin1 Antibody - N-terminal region (ARP42875_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Aliases

Fu, Kb, Ki, Axin, fused, kinky, knobbly, AI316800

Gene ID

12005

Swiss Prot

O70239

Accession Number

XP_920000

Reactivity

Human, Mouse

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Axin1

Target

Axin1 is a component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Axin1 controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. It also facilitates the phosphorylation of APC by GSK3B, facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation and enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7.

Partner Proteins

Lrp5; Gsk3b; Prmt1; Ctnnb1; GSK3A; Trp53; Hipk2; Nck2; Lrrk2; ITCH; WWP1; MAP3K1; Kif3a; Cops2; Dvl2; Axin1; Apc; Dixdc1; Ppp2r1a; Map3k4; Ppp2ca; Rnf111; Rnf11; Smad7; Smad6; Smad3; Dvl1; Cdh2; APC2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TVGRDQALGARQAERPWPPHSHPSTPEPSVRNDGKRRFMGVRRQGSRGAG

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol