PLOD2 antibody - middle region (ARP42731_P050)

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Product Specifications

CAS Number

9007-83-4

Gene Name

Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

Gene Aliases

LH2, TLH, BRKS2

Gene ID

5352

Swiss Prot

O00469-2

Accession Number

NP_891988

Reactivity

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PLOD2

Target

PLOD2 forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Partner Proteins

ITGB1BP2; SUPT5H; CSDE1; SF1; UGP2; TPP2; VASN; RNF123; NUSAP1; SAMHD1; DNPEP; GANAB; SWAP70; XPO7; PACSIN2; FAF1; HSPH1; SEC23A; PRMT3; FARSB; USP15; RANBP3; SET; RPL24; PTPN12; NCL; NARS; JUP; GART; XRCC6; AP2B1; gag-pol; UBL4A; OS9; FBXO6; UBC; VHL; Fa

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

IKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMTLQREKDSPTPETFQM

Applications

IHC, WB

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

85 kDa

Protein Length

758

NCBI Gene Symbol

PLOD2

Host or Source

Rabbit

Protein Name

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Gene Name URL

PLOD2

Nucleotide Accession Number

NM_182943

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