EIF2AK1 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Eukaryotic translation initiation factor 2-alpha kinase 1

Gene Aliases

HCR, HRI, hHRI, LEMSPAD

Gene ID

27102

Swiss Prot

Q9BQI3

Accession Number

NP_055228

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human EIF2AK1

Target

EIF2AK1 acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene.The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme. Sequence Note: The sequence AF181071.1 is a chimeric mRNA clone. Only the heme-regulated initiation factor 2-alpha kinase region was propagated into this RefSeq record.

Partner Proteins

MDM2; UBC; HSP90AA1; LIG4; CDC37; EIF2AK1; EIF2S1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

TCSDEFSSLRLHHNRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALE

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

71 kDa

Protein Length

630

NCBI Gene Symbol

EIF2AK1

Host or Source

Rabbit

Protein Name

Eukaryotic translation initiation factor 2-alpha kinase 1

Gene Name URL

EIF2AK1

Nucleotide Accession Number

NM_014413

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

sc-25291 200 µg/mL

γ1-Adaptin (B-2)

Ask

View Details

49244156 3x 1.0 µg DNA

UQCRQ CRISPR All-in-one AAV vector set (with saCas9)(Rat)

Ask

View Details

RM-P092731-01 10 mg

Pinaverium Bromide Impurity 31

Ask

View Details

RM-P092731-02 25 mg

Pinaverium Bromide Impurity 31

Ask

View Details

RM-P092731-03 50 mg

Pinaverium Bromide Impurity 31

Ask

View Details

RM-P092731-04 100 mg

Pinaverium Bromide Impurity 31

Ask

View Details