MLH3 Antibody - middle region
Product Specifications
CAS Number
9007-83-4
Gene Name
MutL homolog 3 (E. coli)
Gene Aliases
HNPCC7
Gene ID
27030
Swiss Prot
Q2M1Z1
Accession Number
NP_055196
Reactivity
Human
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MLH3
Target
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7) . Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7) . Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
Partner Proteins
MLH1; MYC; FAN1; AR; MLH3; MSH4
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
SMQVLQQVDNKFIACLMSTKTEENGEADSYEKQQAQGSGRKKLLSSTLIP
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
161kDa
Protein Length
1429
NCBI Gene Symbol
MLH3
Host or Source
Rabbit
Protein Name
MutL homolog 3 (E. coli) EMBL AAI12168.1
Gene Name URL
MLH3
Nucleotide Accession Number
NM_014381
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7033168-01 0.02 mg
Recombinant Xanthomonas campestris pv. campestris Undecaprenyl-diphosphatase (uppP)
Ask
View Details MBS7033168-02 0.1 mg
Recombinant Xanthomonas campestris pv. campestris Undecaprenyl-diphosphatase (uppP)
Ask
View Details MBS7033168-03 5x 0.1 mg
Recombinant Xanthomonas campestris pv. campestris Undecaprenyl-diphosphatase (uppP)
Ask
View Details