Cyclizine (hydrochloride)
Cyclizine hydrochloride, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine hydrochloride can be used for the research of nausea, vomiting, and dizziness[1][2][3].
Product Specifications
CAS Number
303-25-3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cyclizine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1.[H]Cl
Molecular Formula
C18H23ClN2
Molecular Weight
302.84
Precautions
P261-P280-P302+P352
References & Citations
[1]Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9 (7-8) :990-5.|[2]Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69 (4) :663-7.|[3]Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22 (2) :293-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Available Sizes
Frequently Asked Questions
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