MSH2 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

MutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Gene Aliases

FCC1, COCA1, HNPCC, LCFS2, hMSH2, HNPCC1, MMRCS2

Gene ID

4436

Swiss Prot

P43246

Accession Number

AAY15096

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2

Target

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC.

Partner Proteins

ESR1; BRCA1; SUMO2; RPA3; RPA2; RPA1; REV1; POLK; DPYSL3; ATP6V1B2; CUL2; XRCC5; SUPT5H; STAT3; ST13; PDE3A; NRD1; JUP; XRCC6; SEC23A; HDAC6; PCNA; MSH3; MSH6; ERCC4; ERCC1; gag-pol; UBC; SUPT16H; SEPT9; SRSF10; SRSF11; SART1; SMARCA5; TOP2B; SRSF7; SRSF5

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

KMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECV

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Yeast: 85%; Zebrafish: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

64kDa

Protein Length

586

NCBI Gene Symbol

MSH2

Host or Source

Rabbit

Protein Name

DNA mismatch repair protein Msh2

Gene Name URL

MSH2

Nucleotide Accession Number

NM_000251

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