DCX antibody - C-terminal region (ARP41332_P050)
Product Specifications
CAS Number
9007-83-4
Gene Name
Doublecortin
Gene Aliases
DC, DBCN, LISX, SCLH, XLIS
Gene ID
1641
Swiss Prot
O43602
Accession Number
NP_000546
Reactivity
Human, Mouse, Dog, Horse, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human DCX
Target
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The protein contains two doublecortin domains, which bind microtubules. In addition, DCX interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex.In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.
Partner Proteins
KIFC3; GOLGA2; TRIM23; KRTAP10-8; KRT40; RINT1; MID2; SPAG5; IKZF1; CALCOCO2; ZBTB5; TRIM27; MEOX1; FBXO25; APP; PPP1R9B; PPP1CA; PAFAH1B1; ACD; TINF2; POT1; TERF1; SPP1; USP9X; NFASC; TRIM39; AP1M1; AP2M1; DCX; CDK5
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
TAGPKASPTPQKTSAKSPGPMRRSKSPADSANGTSSSQLSTPKSKQSPIS
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
49kDa
Protein Length
441
NCBI Gene Symbol
DCX
Host or Source
Rabbit
Protein Name
Neuronal migration protein doublecortin
Gene Name URL
DCX
Nucleotide Accession Number
NM_000555
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