EXOSC6 Antibody - N-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
Exosome component 6
Gene Aliases
P11, EAP4, MTR3, Mtr3p, hMtr3p
Gene ID
118460
Swiss Prot
Q5RKV6
Accession Number
NP_478126
Reactivity
Human, Mouse, Rat, Cow, Pig
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human EXOSC6
Target
EXOSC6 constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly (A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.
Partner Proteins
CEP250; DCP1B; EXOSC6; CHPF; MIF4GD; XRN1; NDUFA13; MRPL4; EXOSC1; MRPS18B; UPF2; RAB3GAP2; SKIV2L2; GSE1; EXOSC7; EXOSC8; ZFP36; TUFM; EXOSC10; MAN2C1; ESRRA; C1QBP; AICDA; DIS3L; EXOSC4; EXOSC3; CUL3; ELAVL1; HDGF; UBC; EXOSC5; DNAJC30; MOCS3; MPP6; EXO
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
MPGDHRRIRGPEESQPPQLYAADEEEAPGTRDPTRLRPVYARAGLLSQAK
Applications
IHC, WB
Purification
Protein A purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
1.0 mg/ml
Homology
Cow: 93%; Human: 100%; Mouse: 88%; Pig: 86%; Rat: 93%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
30kDa
Protein Length
272
NCBI Gene Symbol
EXOSC6
Host or Source
Rabbit
Protein Name
Exosome complex component MTR3
Gene Name URL
EXOSC6
Nucleotide Accession Number
NM_058219
Curated Selection
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