Jervine
Product Specifications
UNSPSC Description
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC50 of 500-700 nM[1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties[2].
Target Antigen
Hedgehog; Smo
Type
Natural Products
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Jervine.html
Purity
98.03
Solubility
DMSO : 1 mg/mL (ultrasonic)
Smiles
O=C1[C@]2([H])[C@]3(C)C(C[C@@H](O)CC3)=CC[C@@]2([H])[C@]4([H])CC[C@]5(O[C@@]6([H])[C@@]([C@H]5C)([H])NC[C@@H](C)C6)C(C)=C41
Molecular Weight
425.60
References & Citations
[1]Williams JA, et al.Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basalcell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.|[2]Dumlu FA, et al.Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album.Phytomedicine. 2019 Mar 1;55:191-199.|[3]Ghezali L, et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a pro-apoptotic effect.Exp Cell Res. 2013 Apr 15;319(7):1043-53.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0836/Jervine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0836/Jervine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
469-59-0
Available Sizes
Curated Selection
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