DIS3 Antibody - N-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

DIS3 mitotic control homolog (S. cerevisiae)

Gene Aliases

RRP44, dis3p, EXOSC11, KIAA1008, 2810028N01Rik

Gene ID

22894

Swiss Prot

Q9Y2L1

Accession Number

NP_055768

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human DIS3

Target

DIS3, belonging to the ribonuclease II (RNB) family, has a 3'-5' exonuclease activity. It is a catalytic component of the exosome 3'->5' exoribonuclease complex required for the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and for mRNA decay. The protein is implicated in mitotic control and essential for cell division and spore germination. It may be involved in regulating protein dephosphorylation during mitosis.

Partner Proteins

SUMO2; UBC; TWF1; NTMT1; EXOSC8; EXOSC10; AICDA; WDR1; STXBP3; PPP5C; SH3PXD2B; EXOSC5; EXOSC4; EXOSC1; EXOSC3; SKIV2L2; EXOSC2; EXOSC7; DIS3; EXOSC9; CUL3; CUL5; SIRT7; BABAM1; EXOSC6; MPP6; ZBTB17

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

DIVAVELLPKSQWVAPSSVVLHDEGQNEEDVEKEEETERMLKTAVSEKML

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 79%; Dog: 93%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 85%; Pig: 93%; Rabbit: 86%; Rat: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

109kDa

Protein Length

958

NCBI Gene Symbol

DIS3

Host or Source

Rabbit

Protein Name

Exosome complex exonuclease RRP44

Gene Name URL

DIS3

Nucleotide Accession Number

NM_014953

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