NFATC1 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Gene Aliases

NFAT2, NFATc, NF-ATC, NF-ATc1.2

Gene ID

4772

Swiss Prot

B5B2M5

Accession Number

NP_765975

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human NFATC1

Target

NFATC1 is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Partner Proteins

YWHAQ; OGT; PML; GZF1; FOXP3; HDAC4; PIAS1; SUMO1; UBE2I; RPS6KB1; RPS6KA3; HDAC2; HDAC1; HNRNPA1; TUBA1A; KPNB1; HDAC5; KAT2B; EP300; PARP1; HDAC3; PPP3R1; MAPK14; GNB2L1; PRKCA; SPI1; PIM1; EGR2; EGR1

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

LLPEVHEDGSPNLAPIPVTVKREPEELDQLYLDDVNEIIRNDLSSTSTHS

Applications

WB, IHC

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 79%; Dog: 93%; Guinea Pig: 91%; Horse: 91%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 86%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

100kDa

Protein Length

930

NCBI Gene Symbol

NFATC1

Host or Source

Rabbit

Protein Name

Nuclear factor of activated T-cells c1 isoform IB-IXL EMBL ACG55580.1

Gene Name URL

NFATC1

Nucleotide Accession Number

NM_172387

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