GATAD2B antibody - N-terminal region (ARP39429_P050)

Product Specifications

CAS Number

9007-83-4

Gene Name

GATA zinc finger domain containing 2B

Gene Aliases

P68, GANDS, MRD18, P66beta

Gene ID

57459

Swiss Prot

Q8WXI9

Accession Number

NP_065750

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human GATAD2B

Target

Hp66beta (GATAD2B), previously identified as a component of the human MeCP1 complex, is a second member of a p66 gene family (hp66alpha and hp66beta) . Both proteins interact with MBD2 and MBD3 functionally and biochemically. Both factors function in synergy, since knocking-down p66alpha affects the repressive function of p66beta and vice versa. Furthermore, confocal microscopy shows a nuclear colocalization of hp66alpha with hp66beta and MBD2 in a speckled pattern. These two highly related mammalian p66 proteins display overlapping functions and are involved in methylation dependent transcriptional repression.

Partner Proteins

USHBP1; CEP70; RPGRIP1; TEX11; MBD3; TRIM27; PRKAB2; GOLGA2; CALCOCO2; TRAF1; SUMO2; UBC; ZBTB1; SUZ12; EED; RNF2; HDAC2; HDAC1; SMAD2; MTA3; NOTCH1; MTA2; MTA1; NDUFA7; NDUFA2; SOX2; PARK7; tat; HIST1H4A; HIST1H3A; HIST2H2BE; HIST2H2AC; RBBP7; RBBP4; Fox

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLK

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

65kDa

Protein Length

593

NCBI Gene Symbol

GATAD2B

Host or Source

Rabbit

Protein Name

Transcriptional repressor p66-beta

Gene Name URL

GATAD2B

Nucleotide Accession Number

NM_020699

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