ZNF446 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Zinc finger protein 446

Gene Aliases

ZSCAN30, ZSCAN52, ZKSCAN20

Gene ID

55663

Swiss Prot

Q9NWS9

Accession Number

NP_060378

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ZNF446

Target

ZNF446 contains a KRAB and three C (2) H (2) zinc fingers. ZNF446 is a transcription repressor when fused to GAL4 DNA-binding domain and co-transfected with VP-16. Overexpression of ZNF446 in COS-7 cells inhibits the transcriptional activities of SRE and AP-1, suggesting that the ZNF446 protein may act as a transcriptional repressor in mitogen-activated protein kinase (MAPK) signaling pathway to mediate cellular functions.

Partner Proteins

NOTCH2NL; KRTAP10-3; ZSCAN22; ZNF396; KRT40; ZNF496; PGBD1; LZTS2; ZNF397; ZSCAN16; ZKSCAN7; ZNF446; ZSCAN32; ZNF232; ZSCAN9; ZNF165; ZSCAN21; ZNF24; TRIM27; PIN1; DGCR6; ACTN2; FHL5; DGCR6L; SUFU; ZNF263

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

SYPCEECGCSFSWKSQLVIHRKSHTGQRRHFCSDCGRAFDWKSQLVIHRK

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 86%; Dog: 93%; Guinea Pig: 93%; Horse: 75%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

49kDa

Protein Length

450

NCBI Gene Symbol

ZNF446

Host or Source

Rabbit

Protein Name

Zinc finger protein 446

Gene Name URL

ZNF446

Nucleotide Accession Number

NM_017908

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