HOIPIN-1

HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro[2].

Product Specifications

Product Name Alternative

JTP-0819958

UNSPSC

12352005

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hoipin-1.html

Purity

99.57

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(O[Na])C1=CC=CC=C1/C=C/C(C2=CC=CC=C2OC)=O

Molecular Formula

C17H13NaO4

Molecular Weight

304.28

References & Citations

[1]Ken Katsuya, et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF) -Based Assay System. SLAS Discov. 2018 Dec;23 (10) :1018-1029|[2]Ken Katsuya, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.