HOIPIN-1
HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro[2].
Product Specifications
Product Name Alternative
JTP-0819958
UNSPSC
12352005
Target
IKK
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hoipin-1.html
Purity
99.57
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C(O[Na])C1=CC=CC=C1/C=C/C(C2=CC=CC=C2OC)=O
Molecular Formula
C17H13NaO4
Molecular Weight
304.28
References & Citations
[1]Ken Katsuya, et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF) -Based Assay System. SLAS Discov. 2018 Dec;23 (10) :1018-1029|[2]Ken Katsuya, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-α; IKK-β
Available Sizes
Curated Selection
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