SAFB Antibody - N-terminal region

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Product Specifications

CAS Number

9007-83-4

Gene Name

Scaffold attachment factor B

Gene Aliases

HAP, HET, SAF-B, SAFB1, SAB-B1, SAF-B1

Gene ID

6294

Swiss Prot

Q15424-2

Accession Number

NP_002958

Reactivity

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SAFB

Target

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA) . This protein is thought to be involved in attachingthe base of chromatin loops to the nuclear matrix but there isconflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factorsare a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serveas a molecular base to assemble a 'transcriptosome complex' in thevicinity of actively transcribed genes. It is involved in theregulation of heat shock protein 27 transcription, can act as anestrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcriptvariants encoding different isoforms have been found for this gene.

Partner Proteins

SUMO3; STAU1; UBC; LGR4; SUMO1; EED; rev; TP63; IL7R; CSNK2A1; MAP1LC3A; TP53BP1; TRMT112; TMOD2; RBMX; NCSTN; ACIN1; SMU1; U2AF2; CPSF6; GCN1L1; UTP14A; USP39; SAP18; VTN; U2AF1; TPBG; SURF4; SON; SRSF7; PRKAR1A; ABCC1; LAMP2; SEPT7; AK2; ACAT1; ZC3H18

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDS

Applications

Purification

Affinity purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rat: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

93 kDa

Protein Length

848

NCBI Gene Symbol

SAFB

Host or Source

Rabbit

Protein Name

Scaffold attachment factor B1

Gene Name URL

SAFB

Nucleotide Accession Number

NM_002967.3

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