ATF4 Antibody - C-terminal region

Product Specifications

CAS Number

9007-83-4

Gene Name

Activating transcription factor 4 (tax-responsive enhancer element B67)

Gene Aliases

CREB2, TXREB, CREB-2, TAXREB67

Gene ID

468

Swiss Prot

P18848

Accession Number

NP_001666

Reactivity

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Sheep, Yeast

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ATF4

Target

ATF4s a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

Partner Proteins

GPS2; GOLGA1; EP300; CEBPG; GOLGA8F; GOLGA8EP; GCC1; TRIB3; CCDC106; LDOC1; FBXW11; NDC80; BTRC; BFSP2; DDIT3; CREBBP; NEK6; JUN; FOS; ATF2; CEBPE; CEBPA; ATF4; ATF3; BATF2; CREBZF; BATF3; BATF; CREB3; MAFB; FOSL1; NFE2L2; NFE2; MAF; UBC; TGM2; RPS6; MAP2

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

EQNKTAATRYRQKKRAEQEALTGECKELEKKNEALKERADSLAKEIQYLK

Applications

Purification

Protein A purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

1.0 mg/ml

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 93%; Sheep: 93%; Yeast: 82%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

39kDa

Protein Length

351

NCBI Gene Symbol

ATF4

Host or Source

Rabbit

Protein Name

Cyclic AMP-dependent transcription factor ATF-4

Gene Name URL

ATF4

Nucleotide Accession Number

NM_001675

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