MDC1 Antibody - C-terminal region
Product Specifications
CAS Number
9007-83-4
Gene Name
Mediator of DNA-damage checkpoint 1
Gene Aliases
NFBD1
Gene ID
9656
Swiss Prot
Q14676
Accession Number
NP_055456
Reactivity
Human, Dog, Guinea Pig
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1
Target
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Partner Proteins
RPA3; RPA2; RPA1; EED; TOPBP1; RNF8; UBC; LMNA; RAG1; CDC27; NCL; NBN; MRE11A; CSNK2A1; RAD50; CAPZB; CAPZA1; AUP1; ATP2A2; LOC729324; CHAMP1; HNRNPUL2; PGAM5; LSM12; ANAPC16; OSBPL8; DTX2; ZNF251; RBM17; FAM175A; LAS1L; LPCAT1; MYH14; SLC25A22; ZNF768; H
Clonality
Polyclonal
Type
Polyclonal Antibody
Sequence
GKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGV
Applications
WB
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions
Reconstitution & Storage Instructions
Western Blotting/Immunoblotting (WB/IB) Protocol
Western Blotting/Immunoblotting (WB/IB) Protocol
Immunohistochemistry (IHC) Protocol
Immunohistochemistry (IHC) Protocol
Immunocytochemistry (ICC) Protocol
Immunocytochemistry (ICC) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
Blocking Peptide Competition Protocol (BPCP)
Blocking Peptide Competition Protocol (BPCP)
Immunoprecipitation (IP) Protocol
Immunoprecipitation (IP) Protocol
Antibody Array (AA) Protocol
Antibody Array (AA) Protocol
Concentration
0.5 mg/ml
Homology
Dog: 86%; Guinea Pig: 92%; Human: 100%
Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
227kDa
Protein Length
2089
NCBI Gene Symbol
MDC1
Host or Source
Rabbit
Protein Name
Mediator of DNA damage checkpoint protein 1
Gene Name URL
MDC1
Nucleotide Accession Number
NM_014641
Curated Selection
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