What is the catalog number for MDC1 antibody - C-terminal region (ARP36798_P050)?

The catalog number for MDC1 antibody - C-terminal region (ARP36798_P050) is ARP36798_P050.

What sizes are available for MDC1 antibody - C-terminal region (ARP36798_P050)?

MDC1 antibody - C-terminal region (ARP36798_P050) is available in the following size(s): 100 µL.

Is MDC1 antibody - C-terminal region (ARP36798_P050) in stock?

MDC1 antibody - C-terminal region (ARP36798_P050) is currently made to order / not held in immediate stock. Contact us for lead time.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

MDC1 antibody - C-terminal region (ARP36798_P050)

Selected Variant

ARP36798_P050

Size: 100 µL

Product Specifications

CAS Number

9007-83-4

Gene Name

Mediator of DNA-damage checkpoint 1

Gene Aliases

NFBD1

Gene ID

9656

Swiss Prot

Q14676

Accession Number

NP_055456

Reactivity

Human, Dog, Guinea Pig

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human MDC1

Target

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Partner Proteins

RPA3; RPA2; RPA1; EED; TOPBP1; RNF8; UBC; LMNA; RAG1; CDC27; NCL; NBN; MRE11A; CSNK2A1; RAD50; CAPZB; CAPZA1; AUP1; ATP2A2; LOC729324; CHAMP1; HNRNPUL2; PGAM5; LSM12; ANAPC16; OSBPL8; DTX2; ZNF251; RBM17; FAM175A; LAS1L; LPCAT1; MYH14; SLC25A22; ZNF768; H

Clonality

Polyclonal

Type

Polyclonal Antibody

Sequence

GKEEDVVTPKPGKRKRDQAEEEPNRIPSRSLRRTKLNQESTAPKVLFTGV

Applications

Purification

Affinity Purified

Assay Protocol

Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

Concentration

0.5 mg/ml

Homology

Dog: 86%; Guinea Pig: 92%; Human: 100%

Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Reconstitution

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Molecular Weight

227kDa

Protein Length

2089

NCBI Gene Symbol

MDC1

Host or Source

Rabbit

Protein Name

Mediator of DNA damage checkpoint protein 1

Gene Name URL

MDC1

Nucleotide Accession Number

NM_014641

Price

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