UNC2399
UNC2399, a biotinylated UNC1999, is a selective EZH2 inhibitor, maintaining high in vitro potency for EZH2, with an IC50 of 17 nM[1][2].
Product Specifications
CAS Number
[2412791-72-9]
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc-2399.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC(C=C(NC1=O)C)=C1CNC(C2=C3C(N(N=C3)C(C)C)=CC(C4=CN=C(N5CCN(CC5)C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]7([H])[C@](NC(N7)=O)([H])CS6)=O)=O)C=C4)=C2)=O
Molecular Formula
C67H104N10O17S
Molecular Weight
1353.66
References & Citations
[1]Konze KD, et, al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013; 8 (6) : 1324-34.|[2]Ma A, et, al. Discovery of a first-in-class EZH2 selective degrader. Nat Chem Biol. 2020 Feb;16 (2) :214-222.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2
Available Sizes
Curated Selection
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